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In the terrifically smart and genuinely inspiring comedy Brittany Runs a Marathon, Jillian Bell stars as Brittany, a 27-year-old New Yorker who decides to turn her life around. When we first meet Brittany, she has a dead-end job at a small theater and spends most of her nights out drinking and partying with friends. She gets in shape, takes up long-distance running and decides to give the New York City Marathon a try.

Federal and state officials say illegal marijuana grows on California’s public lands pose a danger not only to the environment, but to consumers.

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One of the ways Native tribes in the West celebrate their history and culture is through annual summer horse races. They're known as Indian Relays, and tribes call them America's first extreme sport.

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So there's a new outbreak of plague just outside Denver, not among humans but rather among prairie dogs. Some parks have been partially closed through Labor Day as staffers try to stop the spread.

The city of Portland has teamed up with the Portland Business Alliance, Travel Portland and other agencies to encourage people to visit downtown businesses this Saturday, as a part of the “Shop. Eat. Play.” campaign.

Mayor Ted Wheeler said many downtown businesses were negatively affected by last weekend's rally. Numerous businesses large and small closed ahead of the demonstrations.

“The goal of the ‘Shop. Eat. Play.’ campaign is to help downtown businesses recover some of their losses,” Wheeler said in a news release.

Lyubov Sobol looks frail after ending a monthlong hunger strike. The unexpected protagonist of equally unexpected anti-government demonstrations in the Russian capital this summer, she speaks softly and chooses her words deliberately.

"My daughter is 5 years old," she says in an interview with NPR. "I want her to live in a country where human rights and freedoms are respected, where the courts are independent, and where there is a free press. I want her to live in this country. I don't want to move away."

The pilot who was forced to ditch his newly purchased aircraft in the ocean off the coast of Half Moon Bay on Tuesday said he believes bad gasoline caused the plane to malfunction.

The Federal Aviation Administration and the National Transportation Safety Board are investigating. FAA spokesman Ian Gregor said investigators had not yet spoken to pilot David Lesh.

A Baltimore County judge has sentenced Dawnta Harris to a life term in prison for the murder of police Officer Amy Caprio. Harris was 16 when the stolen Jeep he was driving ran over Caprio, 29, in the spring of 2018.

Within days of Caprio's death, Harris was charged as an adult, facing a count of first-degree murder.

The Trump administration struck a tentative deal to lift tariffs on imported tomatoes from Mexico. But importers warn the agreement could still put protectionist roadblocks in the path of $2 billion worth of the produce.

Mexico supplies more than half the fresh tomatoes sold in the U.S., and imports have more than doubled since 2002. Florida growers, who used to dominate the market for tomatoes in the winter and spring, have long complained that Mexico unfairly subsidizes its tomato crop.

Assemblyman Tyler Diep remembers what he saw as a wide-eyed 8-year-old boy arriving in San Diego with his mom and dad from their native Vietnam in 1991: “Clean. Quiet. Big, compared to Saigon.”

His parents had waited eight years to be allowed to come to America. They spoke no English when they settled into their first apartment near San Diego State University. They had no money, no job — nothing other than aspirations of attaining their piece of the American Dream. They could not have made it without a little help from the government in their home.

President Trump said he is willing to get behind some changes to background checks for gun buyers as long as Democrats don't move the goalposts and lead him down a "slippery slope."

The president told reporters on Wednesday that he continues to support new or altered checks, without going into detail, and he acknowledged that he has been taking counsel on the issue from the National Rifle Association.

Congressional budget forecasters are predicting more red ink — nearly $1 trillion this year — as a result of the bipartisan spending agreement lawmakers struck this summer.

The nonpartisan Congressional Budget Office now says the federal deficit will hit $960 billion in fiscal 2019 and average $1.2 trillion in each of the next 10 years.

At some point nearly everyone has to deal with pain.

How do Americans experience and cope with pain that makes everyday life harder? We asked in the latest NPR-IBM Watson Health Poll.

First, we wanted to know how often pain interferes with people's ability to work, go to school or engage in other activities. Overall, 18% of Americans say that's often a problem for them. Almost a quarter – 24% — say it's sometimes the case.

Naked mole rats don't look like they'd be one of nature's superstars. They're about the size and shape of small sweet potatoes. These rodents are native to the grasslands of East Africa, and are mostly hairless, wrinkled, and blind. And yet, they've evolved some special behaviors and features that help them thrive in harsh environments in which other mammals (humans included) would wither.

In mice, scientists have used a variety of drugs to treat brain disorders including murine versions of Alzheimer's disease, depression and schizophrenia. But in people, these same treatments usually fail.

And now researchers are beginning to understand why.

A detailed comparison of the cell types in mouse and human brain tissue found subtle but important differences that could affect the response to many drugs, a team reports Wednesday in the journal Nature.

In the terrifically smart and genuinely inspiring comedy Brittany Runs a Marathon, Jillian Bell stars as Brittany, a 27-year-old New Yorker who decides to turn her life around. When we first meet Brittany, she has a dead-end job at a small theater and spends most of her nights out drinking and partying with friends. She gets in shape, takes up long-distance running and decides to give the New York City Marathon a try.

Copyright 2019 Fresh Air. To see more, visit Fresh Air.

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This is FRESH AIR. I'm Dave Davies, in for Terry Gross, who's off this week. You might not recognize the name of our guest Stephen Root, but chances are awfully good you've seen his work. He's a character actor who's appeared in nearly 800 TV episodes and a hundred movies and sometimes brief appearances, like one as a bank manager on "Seinfeld" or his short but memorable scenes as the sad sack office worker Milton in the film "Office Space." He's had several recurring roles in TV series over the years, including "The West Wing," "NewsRadio" and "Justified."

The Trump administration has announced it is ending a federal court agreement that limits how long migrant families with children can be detained.

Acting Homeland Security Secretary Kevin McAleenan outlined the new policy Wednesday, which replaces the Flores Settlement agreement. That’s been a longtime target of immigration hard-liners in the Trump administration, who contend the settlement has acted as a lure to families in Central America.

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Updated at 3:34 p.m. ET

The Trump administration has announced it is ending a federal court agreement that limits how long migrant families with children can be detained.

Acting Homeland Security Secretary Kevin McAleenan outlined the new policy Wednesday, which replaces the Flores settlement agreement.

That's been a longtime target of immigration hard-liners in the Trump administration, who contend the settlement has acted as a lure to families in Central America.

Call it The Film About Rich People Hunting Poor People ... That Lived.

But that's a mouthful. Maybe The Hunt Strikes Back; it's pithier.

Just two weeks ago, Ready or Not seemed poised to represent a second data point in 2019's "Murderous, Mansion-Dwelling One-Percenters In Film" trend graph, preceded by Craig Zobel's "blue bloods vs. red staters" thriller The Hunt and followed in November by Rian Johnson's latter-day Clue riff, Knives Out.

It's a windy, hazy summer morning on the Snake River plain in southeastern Idaho, and Shoshone-Bannock tribal member Trevor Beasley is hanging out near his horse trailer. It's about an hour before the Fort Hall Reservation Indian Relay races begin, and he's watching as a teammate gets a little too close to his favorite mare.

"Got to watch out for her, she's a kicker," Beasley says as his teammate jumps out of the way. "That's your warning right there, man."

The San Francisco Municipal Transportation Agency narrowly voted late Tuesday to name the new Chinatown subway station after Rose Pak, a controversial figure in local politics who fought to bring the subway to the neighborhood.

Scores of people spoke in passionate support — and opposition — to naming the station after Pak, who died in 2016 at age 68. Many spoke in Chinese, using a translator, while others brought videos to show the agency’s seven-member board of directors during the hearing. Public comment lasted for about six hours.

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We continue our series about Interstate 5 with Vancouver Mayor Anne McEnerny-Ogle. She has been a vocal proponent of a new interstate bridge between Vancouver and Portland. 

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Acting Secretary of Homeland Security Kevin McAleenan announced changes just this morning to how long government can detain migrant children. Here he is.

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A South African court is restricting gratuitous displays of the country's old apartheid-era flag, calling the banner "a vivid symbol of white supremacy and black disenfranchisement and suppression."

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