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Disgraced financier Bernard Madoff appeared in federal court in New York Thursday and pleaded guilty to running a multibillion dollar Ponzi scheme. The judge denied a request from Madoff's lawyer that he remain free until sentencing in June, sending Madoff to jail.

Hillary Clinton won a narrow victory in Indiana on Tuesday and lost by a significant margin to Barack Obama in North Carolina. Howard Wolfson, communications director for Clinton's campaign, talks with Michele Noris about how Clinton can get from here to the nomination, and what her pitch is to superdelegates who may be moving closer to endorsing Obama.

The nation's unemployment rate last month is the highest it's been in more than 25 years. However, the pace of layoffs eased. Employers cut 345,000 jobs in May, the fewest since September.

Sen. Barack Obama topped Democratic rival Hillary Clinton in Tuesday's Mississippi primary. Despite overwhelming support in the African-American community for Obama, exit polls showed that he lost ground with white voters in what turned out to be the most racially polarized vote so far.

Cyclist Floyd Landis has lost his doping case and with it his claim to the 2006 Tour de France title. An arbitration panel upheld the results of a test that showed Landis used synthetic testosterone to fuel his victory. Landis has the right to appeal.

Americans observe the sixth anniversary of the Sept. 11 attacks, with soldiers in Afghanistan lowering the flag to half-staff at a U.S. base while victims' relatives gathered at ceremonies in New York, Washington and Pennsylvania.

Many of the people who lost money in the alleged fraud case involving Bernard Madoff were sophisticated and successful. It may be surprising to learn that those investors put billions of dollars into what is being labeled as one of the biggest Ponzi schemes in history. The sums may be shocking, but the dynamics at work in the case are familiar.

While many people lost money with disgraced investor Bernard Madoff, some actually made money. Will they have to give any of it back, as defrauded investors line up to sue?

Federal officials are investigating why two Northwest Airlines-Delta pilots overshot the Minneapolis-St. Paul airport this week, on a flight from San Diego. Controllers lost contact with the pilots during the flight. The pilots say they missed the airport because they were in a heated argument, but there are also questions of whether they might have fallen asleep.

It was John McCain's night to shine Thursday at the Republican National Convention in St. Paul, Minn. In accepting the party's presidential nomination, McCain promised to work against constant partisan rancor and reach across party lines. McCain and his running mate, Sarah Palin, aren't wasting any time and began the day campaigning in Wisconsin.